Immediate Dentin Sealing Of Crown Health And Social Care Essay

Immediate Dentin seal Of capital Health And Social C be EssayBackground Dental elevations be ideal coming back to protect teeth that turn every tail end been extremely worn down, broken, weakened by caries, and heavily filled or root stubal treated. They can be in similar manner used for aesthetic purposes. Full crown preparation requires more than tooth removal than other restorations and is associated with dentin exposure. When a two-st eon crown fabrication is planned, there is a assay of bacterial contamination of the pulpal tissue through dentin and eventually vitality loss. The main objective of this communications protocol is to assess whether neighboring(a) seal of the exposed dentine surface following crown preparation of back teeth can lead to a decrease in microleakage and bacterial infiltration from the oral surround.Methods This protocol, immediate dentine sealing of crown preparations, demonstrates a model for a oneness year, ternary years and six yea rs follow-up, in-vivo, randomised correspondled trial with a balance pr each(prenominal)ing allocation of 11 (immediate dentine sealing vs. delayed sealing). The treatment leave behind include tooth preparation, impression taking, temporary crown placement and effective crown fit on a posterior tooth.Discussion The results of the study would provide insight into the question of whether immediate sealing of dentine afterwards crown preparation reduces the bacterial ingression and incidence of vitality loss of teeth. The results would also help to provide evidence based suggestions for clinicians and other researchers.OverviewThis dissertation consists of literature look backward and a representation of the study design and methodology, followed by data management, statistical analysis and quality assurance of proposed study. Other sections atomic number 18 allocated to ethical consideration and reflection on thesis procedure.DECLARATIONNo portion of the work referred to in the dissertation has been submitted in support of an application for a nonher degree or skill of this or either other university or other institute of learning.INTELLECTUAL PROPERTY STATEMENTThe author of this dissertation (including any appendices and/or schedules to this dissertation) owns certain copyright or related rights in it (the Copyright) and s/he has given The University of Manchester certain rights to use such Copyright, including for administrative purposes.Copies of this dissertation, either in full or in extracts and whether in hard or electronic copy, may be made only in accordance with the Copyright, Designs and Patents Act 1988 (as amended) and regulations issued under it or, where appropriate, in accordance with licensing agreements which the University has entered into. 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Such Intellectual Property and Reproductions cannot and must not be made available for use without the earlier written permission of the owner(s) of the relevant Intellectual Property and/or Reproductions.Further information on the conditions under which disclosure, publication and commercialisation of this dissertation, the Copyright and any Intellectual Property and/or Reproductions described in it may take place is available in the University IP Policy (see http//documents.manchester.ac.uk/display.aspx?DocID=487), in any relevant Dissertation restriction declarations deposited in the University Library, The University Librarys regulations (see http//www.manchester.ac.uk/ library/aboutus/regulations) and in The Universitys Guidance for the Presentation o f Dissertations.AcknowledgementsI hit great pleasure to express my gratitude to my Tutor(Juliette Kendall). She has been most helpful and supportive throughout. instauration, Research question and PICO1.1 IntroductionRestoring teeth with full-coverage crowns is a unremarkable treatment in general dental practice. This normally requires two visits, one for crown preparation and impression taking and one for terminal cementation of the crown once the restoration has been produced in the dental laboratory. Provisional crowns which pass on be provided to protect the tooth surrounded by two visits could cause problems since they are not bonded to the ready tooth surface long-lastingly and require removal forward to final cementation. Problems may occur if the bacteria from oral cavity gain access to the pulpal tissue. The moment could be pulp inflammation or even irreversible pulp transmittance, which requires endodontic treatment. There are some evidence in the literature that suggests that applying a sealer hearty on the fresh wide-awake teeth may reduce the invasion of the pulp by bacteria (Magne et al., 2007). Any effort inevitably to be made to reduce the risk of vitality loss in teeth requiring a full-coverage crown.There are other alternatives to reduce the bacterial ingression like CAD/CAM technology. This method allows restoring a tooth with a crown in a single visit. Reis 2006 believes that using this system may decrease the possibility of bacterial infection of the pulp as there is no need for provisional coverage of the prepared tooth.1.2 Research questionProtecting the exposed dentine with a sealant after a crown preparation requires some additional steps and is more expense and sentence-consuming than the traditional procedure. The research question is if it is clinically indispensable to seal the exposed dentine immediately after the preparation with a dentine sealing gene or not.1.3 PICOPopulation NHS and private patients between t he age of 18 and 58 years of age in general dental practice requiring full-coverage crowns of a posterior tooth.Intervention Sealing the exposed dentine of prepared teeth for full crown coverage with a dentine sealing agent instantly after the preparation in the lead taking a final impression and temporisation.Control Not sealing the exposed dentine of prepared teeth for full crown coverage with a dentine sealing agent instantly after the preparation.Outcome measure Comparing the vitality loss of the prepared teeth for full crown restoration at one year, three years and six years.Aims and objectivesAimsThe aim of the study is to evaluate the efficiency of instant sealing of posterior teeth prepared for full crown coverage prior to impression taking and temporisation in footing of vitality loss compared with teeth without any sealant application.ObjectivesThe primary objective is to assess whether an instant sealing of prepared posterior teeth for full crown restorations with a den tine sealant results in a reduction in vitality loss.To organise a clinical trial and to allocate two groups of participants (NHS and private) aged between 18 and 58 requiring a crown on a posterior tooth. One group impart shake off their prepared teeth covered and one group not.To analyse the achieved data and to determine whether there is a difference between groups in terms of loss of vitality. publications review3.1 IntroductionThe assumption of this protocol is the proposition that the instantaneous sealing of exposed dentine after crown preparation, go out help against the bacterial contamination of the pulpal tissue and decreases the probability of the treated tooth requiring root canal treatment in the future.3.2 Search StrategyThe strategy conducted for this literature review include an electronic search of the following databases EMBASE (1995 Oct 2011), MEDLINE (1995 Oct 2011) and Cochrane Library. The reference list includes hand-searched articles and key journals re lated to researching.Key words REFER TO KEY WORD EITHER HERE OR APPENIX3.3 BackgroundWhere tooth destruction by dental disease is extensive, restoration may only be possible with full coverage restorations or crowns. There is a big number of NHS and private patients in UK requiring a full coverage of posterior teeth due to failed huge previous restorations, fractured cusps or following a root canal therapy. Tooth preparation for full coverage crown requires more tooth removal than other restorations. It should be carried out in a conservative mien. The think is to reduce the post-preparation sensitivity and pulp tissue protection in vital teeth and to maximise the remaining tooth structure.3.4 Crown Preparation and pulpHealth of pulp tissue can be affected by any restorative treatment. This is due to a continuous extension between dentinal and pulpal fluid (Pashley 1992).Preparation for a full-coverage restoration requires removal of most of the enamel resulting in an exposed dent ine surface and may affect the pulp. In one study by capital of Mississippi et al. (1992) irreversible pulpitis occurred in5.7% of cases in which crowns were placed. The bigger the exposed dentine surfaces during tooth preparation like for a crown, the greater the risk of bacterial infiltration from the oral environment (Pashley, 1990).Saunders and Saunders (1998) considered the vitality loss in adults who received full crowns in a dental hospital based on radiographic analysis and found that 19% of the patients in the study have lost vitality of the prepared teeth.A study by Cheung et al. (2005) aimed to investigate the influence of pointors connected with pulpal damage in teeth restored with porcelain fused to metal (PFM) crowns or crowned as a fixed bridge abutment. The study reveals that the preparation for either of the restorations requires a considerable reduction of dentine and may cause trauma to pulp tissue but the survival rate of pulp in single-unit crowns is higher tha n in abutment teeth.Bergenholtz and Nyman (1984) and Karlsson (1986) demonstrated a permanent pulpal damage rate of 1% year for vital teeth following a crown restoration.3.5 Crown Vs. other restorationsMany previous studies have support the use of indirect intracoronal restorations (porcelain or composite) in vital teeth as advantageous against full-coverage restorations due to their less invasively preparation and more conservative nature (Jackson, 2008, Magne et al., 1996, Dietschi et al., 1994). They have been also considered to be easier to do than a crown and are no more expensive than crowns or root canal treatments.A literature review by Kerschbaum and Vo 1981 showed that inlay restorations at 10 years have 9.5% lower rate of vitality loss compared to full crown restorations. When aesthetic aspect is not the first priority properly designed and provided inlays and onlays have the same longevity and durability as crowns (Jackson, 2008).Cusp replacement with resin composite can be considered as alternative to traditional cusp replacement by crowns due to advanced adhesive technology. Deliperi et al. (2006) highlight that if the bonding agent is not stressed, an acceptable victory rate could be achieved by using this method. According to van Dijken et al. (2001) an indirect cusp replacement restoration with ceramic might be considered indicated. This has the benefit of saving valuable remaining tooth substance and eventually keep downing endodontic therapy.3.6 Dentin BondingThere are recommendations in the literature for sealing the dentine with a dentin Bonding Agent (DBA) following crown preparations in order to minimise the associated complications like hypersensitivity (Clinical Research Associates 1993). Dentine bonding agents have shown to be advantageous over the smear layer itself due to their mechanical retention (Nakabayashi et al. 1982) and moisture and acid resistance (Brunton et al. 2000). Over the last decades they have been considered as a modern way of sealing exposed dentine (Ferrari M. et al. 1999, Swift EJ et.al 2001).Some authors have compared the effectiveness of DBA with smear layer as a natural barrier. Pashley (1984) states that dentine permeability can be reduced up to 98% when smear layer is produced by slow or fast rotary headpieces but it would not last for more than a few days due to acidic PH from the oral cavity (Kerns DG. et al. 1991) .There are several advantages of DBAs over the smear layer like mark layer as described by Nakabayashi (1982) and resisting moisture and acid (Brunton et al. 2000).The result of various in-vitro studies on humans teeth (Pashley et al. 1992, White et al. 1992, Al-Fawaz et al. 1993) and animals teeth (Suzuki et al. 1994) supports the idea of sealing the dentine of prepared teeth for a crown restoration. A literature review by Lam, C.W. and Wilson, P.R. (1999) revealed that dentine sealing with bonding agents prior to crown cementation could be beneficial due to fluid fl ow reduction in dentine tubules.Magne (2005) believes that immediate application of dentine bonding agents or Immediate Dentine Sealing (IDS) prior to impression taking can reduce the postoperative sensitivity and bacterial contamination. 35% H3PO4 is normally used to remove the smear layer before DBA application.There are different ways of sealing dentinal tubules after the preparation. Edward and swift (2009) reviewed several in vitro research studies on the immediate dentine sealing proficiency in a critical appraisal and came to following conclusions. First, immediate sealing of fresh dentin improves the resin adhesion and the bond strength leave behind be affected by late application. Second, the IDS provide a mechanical barrier which minimises the postoperative sensitivity, bacterial contamination and eventually the necessity of local anaesthesia.Most Practitioners cull to use self-etch-adhesives. However, Magne et al. (2007) believe that a three-step, etch-and-rinse adhesiv e has shown to be more efficient. In order to avoid complications after the IDS, some clinical steps need to be taken. The appearance of an O2 -inhibitory layer is not desirable and should be prevented by light-curing the dentine adhesive twice under a glycerine coating. This step avoids the reaction between inhibitory layer and impression material. The reaction between temporary crown and sealed tooth should also be prevented by applying a separating material.The influence of dentine on antimicrobial effect of ingredients added to one-step dentine sealants was assessed by Gondim et al. (2008) and revealed a reduced affectivity after polymerisation with UV light.3.7 Temporary CrownsTemporary crowns are provisional restorations that are fitted on the teeth between preparation and fit appointment. They have various functions, mainly dentine protection and tooth movement prevention. Their role is often overlooked by practitioners (Wassel et al. 2002). Pre-formed crowns (plastic, metal) and self or light cured resins are usually used in the dental practices as convenient for temporary restorations.Many temporary crowns have poor-fitting margins based on production procedure and material used. Some materials create a gap between the temporary and the prepared tooth due to polymerisation shrinking (Robinson and Hovijitra, 1982)( Tjan et al. 1987).Cervical border of a temporary crown is the primary area to be reached by bacteria from the oral environment. Richardson et al. (1991) believe that dentine in the cervical margin shows higher permeability than dentine in other surfaces of the prepared tooth and that confirms the importance of good marginal adaptation of temporary crowns.A paper by Cagidiaco et al. (1996) considers the exposure of vital pulp tissue to bacterial contamination and irritants after dentine preparation in the base of a cavity, especially if temporary shows an inadequate sealing. Exposed dentinal tubules after a crown preparation provide a way f or transfer of substances between the pulpal tissue and periphery (Garberoglio and Brannstrom M. 1976). These tubules are evaluate to be sealed by cement. Different researchers (White et al. 1992, White et al. 1994, Lyons. et al, 1997, Baldissare. et al. 1998, Goldman et al. 1992) have found microleakage to be present after either permanent or temporary crown cementation.Literature review supports the evidence of benefit of immediate dentine bonding as a technique during temporisation of indirect provided restorations but reveals a lack of in vivo evidence. This fact supports the requirement for this clinical study.Study design methodologyThe study design and methodology volition be presented in accordance with the CONSORT explanation for reportage on clinical trials (Moher et al., 2010).4.1 Trial DesignThis result be a randomised controlled parallel two- ramp uped trial-pragmatic group trial to take place over the continuance of a six-year period. The study impart provide a 1 1 allocation ratio. One molar tooth will be randomly chosen per participant. The military rating of the outcome will take place at one year, three years and five years (Fig 1).4.1.1 Changes to trial designThe Data Monitoring perpetration (DMC) will have access to the un-blinded data. The study protocol may be altered by DMC due to their recommendations.4.2 ParticipantsParticipant selection will take place utilising new and existing patient population that attends the dental practice. Recruitment will be on a continuous basis until the required numbers of participants have been enrolled into the study (see section 5 for sample size calculation). This will warrant the pragmatic nature of the trial as no proactive recruitment of patients from brochure drops and advertising will take place. A trained member of staff will administrate the consent process once a patient has been determine as having an eligible tooth suited for the study.4.2.1 Inclusion criteria for participantsHealth y adult patients between 18-58 years of ageProvide a written informed consent, understand communicate and written English.Regular attenders (at least every six months) with a two-year recordRequire a full coverage of a Molar (Upper or Lower arch)With a crownSelected tooth must be periodontally healthy.Selected tooth must be vital and without any history of pulpitic symptoms within the last 12 months.Are able to attend follow-up appointments.In terms of periodontal status, the chosen teeth for study have to have a BPE less than three mm as per guidelines published by British Society of Periodontology (BSP). The teeth must be also radiographically free of any pre-operative pathological signs meaning intact pulp with no evidence of radiopaque foreign materials in the pulp chamber and/or root canals(s) and no periradicular radiolucent area.4.2.2 Exclusion criteria for participantsIr continuous attenders to dental practice muniment of pulpitic symptoms in the last 12 monthsPatients part icipating in any other checkup trialsNotable medical history change or pregnancy alert periapical pathology (radiographically)Periodontal pockets more than three mmPulpal exposure or extending caries into the pulp chamberVulnerable adults or children4.3 Study location and settingsThe trial will take place in twenty dental practices based in the United Kingdom. General Dental Practitioners with more than five years experience and qualification in a post-graduate restorative dentistry will be recruited.4.4 WithdrawalsPatients may be disqualified if they experience medical complications or refuse to attend routine check-ups. A patient may also be withdrawn fromthe study if the tooth suffers from a trauma, requires extraction or develops pockets deeper than 3mm due to insufficient oral hygiene. Information on all patients, including the reason for the withdrawal will be collected and added to trial data report. Patients may also choose to withdraw from the study themselves.4.5 Randomi sationinitial selection process will include all teeth that are suitable per patient.To maintain allocation concealment and to limit the occurrence of selection influence (Vickers A.J. 2006) a remote allocation officer in the central generates the allocation of teeth for either the intervention or control group. The participants initials, gender, date of birth and tooth bank bill will be submitted to a centre securely, where randomisation will occur within the patients to select the eligible tooth and to allocate the patient to the treatment or control group using a computer generated sequential number list. The trial will include only one allocated tooth per patient per control or treatment group. The indication of allocation will be sent to the general dental practitioner in an envelope with the patients identification code and the tooth number. The code for trial cadaver hidden until the clinical procedure to treat all eligible teeth is ready. At this time, it will be opened b y the performer but not revealed to the participants.The randomisation will be balanced to a 11 ratio for each provider in each practice. Simple randomisation is suitable to generate a balanced group. Balance between the groups at each location will be verified by the trial allocation operator regularly.4.6 Baseline sound judgmentA baseline examination will be carried out by operators once the suitable patients have completed the consent procedure. The assessment will includePatients Identification, age and genderMedical and social historyDental historyExtra-oral examinationMusculoskeletal assessment, Soft tissue profile, TMJIntra-oral examination oral exam Hygiene, periodontal assessment, soft tissue, occlusal analysis, vitality testing, Ridge mapping,Radiographic evaluation of tooth prior to preparationReason for Crown placement4.7 GDP trainingEach of the operators will attend a one-day training program on techniques. Clinical consensus will be ensured and standardised in a disc ussion with investigators in a freestanding session and will include a clinical protocol for the preparation of teeth for a full coverage with a crown, impression taking and temporisation. special clinical protocols will be prepared for immediate dentine sealing after preparation and for final cementation of the restoration. A clinical team member will be appointed as the independent observer to evaluate the compliance to the study criteria. wholly materials and Instruments used will be applied as per manufacturers instructions. The Crown system used in the study is Cercon ht (Dentsply) full Contour Zirconia. The high strength of zirconia-based ceramic restorations increases the indications for select. They can be a near ideal choice for restoring crowns, fixed partial dentures, and implants in aesthetic areas. Because of their high strength, zirconia-based ceramic restorations can be cemented with traditional cements or bonded with adhesive resin cements. Like gold, Cercon ht ha s a simple, clinical protocol, requiring conservative tooth reductions of as little as 0.5 to 1.0 mm. A feature that is friendly to both patients dentition and dentists chair time. All clinical and laboratory techniques for teeth tough in the study are specified as per Dentsply protocol.4.8 InterventionA universal self-priming dental adhesive system (Prime Bond NT Dual cure, Dentsply) and a ternary cure resin cement (Calibra, Dentsply) will be used to bond the indirect restoration to the tooth. The literature supports the chosen material for this proposed study (Barnes et al., 2006).4.8.1 Intervention protocol for Immediate Dentine Sealing (IDS)The teeth will be sealed immediately after preparation with Prime Bond NT Dual Cure (Dentsply). To avoid any bond contamination, retraction cord will be placed before dentine sealing. The protocol for dentine bonding is as manufacturers instructions abstemious freshly instrumented dentine with water spray and air dry.It is recommended not to etch dentine to minimize the possibility of post-operative sensitivity.Place 1-2 drops of Prime Bond NT adhesive into a clean plastic mixing well. Place an equal number of drops of Self Cure activator into the same mixing well. Mix Contents for 1-2 seconds with a clean, unused clean tip.Immediately apply composite adhesive/activator to thoroughly wet all the tooth surfaces. These surfaces should remain wet for 20 seconds and may necessitate additional application of mixed adhesive/activator.Remove excess solvent by gently drying with clean, dry air at least for 5 seconds. Surface should have a consistent glossy appearance.Cure mixed adhesive/activator for 10 seconds using a curing light. Check curing light for minimum curing output of at least 550mw/cm2 and a spectral output, including 470nm (peak absorption of the CQ photoinitiator).Control GroupExactly the same procedure will be used for the control group prior to final bonding of the Crown.4.8.2 protocol for Impression ta kingStudy Group (IDS)In practice, freshly cut dentin is present only at the time of tooth preparation (before impression). Freshly cut dentin is the ideal substrate for dentin bonding. Most studies on Dentine Bonding Agents (DBA) bond strength use freshly prepared dentin (Magne 2005). There is a possibility for the oxygen inhibition layer of filled resin of the dentine bonding agent to inhibit the setting of the impression material. The bonded teeth have to be cleaned with pumic and a rubber prophylactic cup and washed with water and air dried before the impression (Magne and Nielsen, 2009b). Impressions will be taken with an A-silicone double-mix technique (Aquasil ultra, Dentsply) as per manufactures Instruction.Control Group (no sealing)Impressions will be taken as per study group without sealing the dentine with DSA.4.8.3 Protocol for temporisationStudy Group (IDS)A prefabricated light curable temporary Crown (Protemp Crown temporisation material, 3M ESPE) will be fitted on the prepared tooth standard temporary cements. The obstruction will be controlled and if necessary adjusted.Control groupA temporary crown will be fitted as above without any DBA application and after Impression taking as per clinical consensus guidelines.4.8.4 Protocol for final cementationStudy group (IDS)Just prior to the luting procedures (when placing the final restoration), it is recommended to roughen the existing adhesive resin using a coarse diamond bur at low speed or by microsandblasting (Magne 2005). The tooth and the restoration will be treated as per manufacturers instructions, and the crown can be cemented with dual cure resin (Calibra, Dentsply).Control groupThe same procedure as for study group will be carried out except the adhesive resin roughening step.4.9 OutcomesThe outcome measures will be assessed, and the CRF forms updated at baseline and at recall appointments of 1 year, 3 years and 5 years. Any relevant clinical incident between these times affecting the tria l tooth needs to be recorded on CRF. Base-line findings and post-operative taken periapical (PA) of each trial tooth at one year and five years will be studied, assessed and recorded by two blind assessors. These precalibrated, independent observers will audition the radiographs and categorize the periapical status of the selected teeth according to a written set of criteria(Cheung et al. 2005) (Table 1). Categories 1, 2 or 3 are deemed to be associated with a non-vital pulp. If there are any disagreement, a third assessor will be involved as an arbitrator before a final score is reached.The protocol for Periapicals will adhere to the guidelines produced by the faculty of General Dental Practitioners (Pendlebury et al., 2004). An Independent assessor will audit each practice participating in the study to ensure compliance with radiology regulations (IRMER).4.10 BlindingEvery effort will be made to prevent disclosure of the exact nature of the study aim and to which arm of the study the participants have been allocated. This will be specified to minimise assessment reactivity, which has been hypothesised by McCambridge and Strang (2005).The date collection statistician who assesses and calculates the outcome results will also be blinded to the individual patient allocation to limit detection bias. The operators will not be blinded but the allocation of whether the tooth is to be control or intervention will be concealed until intervention procedure is to be carried out.4.11 Follow upAn important selection criterion to minimise drop-out is the eligibility of the patients to be regular attenders at the relevant dental practices. Patients lost to follow up will be recorded..CategoryStatusDescription0Intact pulpNo evidence of radiopaque foreign materialin pulp chamber and/or root canal(s),and no periradicular radiolucent area1Widening of the poundalspaceWidening of the apical part of the periodontal ligament space, not exceeding two times the width of the lateral periodontal ligament space2Periapical radiolucencyRadiolucency in connection with the apical part of the root, the diameter exceeding two times the width of the lateral periodontal ligament space3Endodontically treatedtoothTooth with radiopaque material in pulp chamber (if discernible) and/or root canal(s)Table 1- Radiographic categorization of pulpal status (Cheung et al. 2005)4.12 SafetyThis study will not be utilising any investigational medicinal products it will therefore be classed as a non- Clinical Trial of an Investigative Medicinal Product trial (non-CMITP). All untoward incidents will be adverse events rather than adverse reaction. The study is also compatible with Data Protection and Mental Capacity Act. The treatment options being studied are non-life threatening on non-vulnerable adults with no risk of harm and no unknown or uncertain risks. A Data Monitoring Committee (DMC) will be appointed who makes recommendations, as required, to the chair of the Trial Steering Co mmittee. This committee is responsible for ensuring that the intervention and control techniques will be carried out under the guidance provided by the EU directive for Good Clinical Practice.4.12.1 Assessment of SafetyThere are no expected unexpected adverse events since the intervention is used routinely in general dental practice. The using of etching gel has expected adverse events should it come into contact with the soft tissues (Material Safety Data Sheet (MSDS) sheet). All other dental materials involved (Prime Bond NT Dual Cure, Calibra dual cure resin cement (Dentsply), Protemp Crown temporisation material, 3M ESPE) are fully licensed within the medical devices regulations for use in dentistry in UK. All operators are experienced dental practitioners having handled these materials routinely and will be trained in dealing with expected adverse reactions should the product inadvertently come into contact with pati